Uno Ultimate from Mattel Games was designed by Aaron Weil. The DC Comics decks are compatible with Marvel Comics editions, allowing for cross-play.

The 1st Edition of UNO Ultimate DC Comics cards was released in June 2023. Each box contains 224 game cards plus a sealed pack of four foil variant cards. The core game cards are divided into four unique character decks: Aquaman, Green Lantern, Superman, and Wonder Woman. Each character deck includes three Enemy Cards, three Event Cards, and two Location Cards.

Separate Add-On Packs for Batman and Harley Quinn were released in August 2023. Each Add-On Pack includes a unique 56-card character deck plus two foil variant cards. An Uno Ultimate core game deck is required to play.

The full-art foil variants are available for Wild and Character cards. The foil cards have five different levels of rarity indicated by a colored dot in the bottom-right corner of each card: 🟣Ultra Rare, 🔴Super Rare, 🟡Rare, 🔵Uncommon, and 🟢Common. The odds for each tier have not been disclosed.

Mattel distributed a free UNO Ultimate Superman foil card at the San Diego Comic-Con International (SDCC) from July 19–July 23, 2023. The artwork reprints the cover of Superman vol. 3, #28 (April 2014). The image was illustrated by Ed Benes and colored by Alex Sinclair.

A free UNO Ultimate Batman foil card was distributed at GenCon in the Indiana Convention Center from August 3–6, 2023. The artwork reprints the cover of Detective Comics #583 (February 1988). The image was illustrated by Mike Mignola and colored by Anthony Tollin.