Series 1 of the Who's Who Mystery Box set from DC Direct was released on May 31, 2006. Each box contains a 2.5 inch micro figure and a matching character profile card. The boxes were sold at Suncoast, Tower Records, and hobby stores. There were three series of Who's Who Mystery Box sets released. A different Superman card is included in each series.

Series 1 boxes are "blind" and there is no indication of what figure and card combination is included. The Series 1 Superman profile card reprints the cover art from Superman #205 (July 2004). The image was penciled by Jim Lee, inked by Scott Williams, and colored by Alex Sinclair.

The back of Series 2 and Series 3 boxes contain a marked checklist.