DC Bloodlines Trading Cards were released by SkyBox International in July 1993. Each box contains 36 packs with 8 cards per pack. The series is comprised of 81 base cards and 4 embossed foil inserts. The artworks were created exclusively for SkyBox and the cards were designed by Arnie Sawyer Studios, Inc. The card text was written by Ruben Diaz. The backs of cards #1–54 assemble a large puzzle illustrated by Christian Alamy.

Promotional materials and special inserts focus on "The Reign of the Supermen!" storyline. The crossover appeared in the annual editions of all four Superman titles published in 1993. Cyborg Superman, Eradicator, Steel, and Superboy (Kon-El) are all featured in the base set. The same four Supermen images appear on embossed foil cards inserted in approximately 1:18 packs. Original artworks from the insert set have been observed in private collections.

An embossed promo card showcases the first four collector's edition covers of "The Reign of the Supermen!" The promo card was packaged with poly-bagged editions of The Adventures of Superman #500, on sale April 15, 1993.

The back of the card asks, "Which, if any, is the real Man of Steel?" The correct answer is none. "The One True Superman" was available through a mail-away redemption that expired on January 15, 1994. Odds of finding the "Superman Redemption Card" are approximately 1:72 packs.

"The One True Superman" is an embossed foil card featuring artwork penciled by Kerry Gammill and inked by Jackson "Butch" Guice. "The One True Superman" was also distributed at various industry events by SkyBox.

The alternate Supermen appear in four-card promo sets packaged with collector editions of The Return of Superman trade paperback. Autographed promo cards were issued by Dynamic Forces. Unnumbered promos were released in four-card cello packs. Promo variants are copyrighted 1994 and do not contain a Bloodlines logo.

Many of the "New Blood" characters that were introduced during the Bloodlines event did not remain in the DC Multiverse continuity. A nine-card Bloodlines subset appears in the 2014 Cryptozoic DC Comics Epic Battles series. In 2016, the concept was revamped as a six-part comic book series during the "New 52" era.