Smallville Trading Cards Seasons 7–10, aka "The Final Seasons," were released by Cryptozoic Entertainment on May 30, 2012. Each box contains 24 packs with 5 cards per pack. Special insert odds are approximately 3:24 packs, or three per hobby box. Fourteen cast members have signed autograph cards for this set. There is one autograph card inserted in each box.

Season 7 of Smallville premiered on The CW Television Network on September 27, 2007. Smallville aired for 10 seasons until the finale on May 13, 2011. The critically acclaimed series followed an adolescent Clark Kent from his adopted Kansas hometown to the big city of Metropolis.

The series finale features Clark finally changing into Superman. The House of El family crest was based on the design from Superman Returns starring Brandon Routh.

"Wardrobe" cards feature show-worn costume memorabilia from seasons 7–10. The odds of finding a "Wardrobe" insert or redemption card are approximately 2:24, or two per hobby box. Redemptions could be exchanged for a 4x6 inch dual-relic worn by Tom Welling. Cryptozoic released an album binder with an exclusive "Wardrobe" card featuring authentic pieces of The Blur's black t-shirt

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Dean Cain, who previously portrayed Clark in Superman & Lois: The New Adventures of Superman, guest-starred as the immortal Dr. Curtis Knox.

Helen Slater guest starred on Smallville as Lara-El, the biological mother of Clark Kent, in season 7 and 10. Slater previously starred as Clark's cousin Kara Zor-El in the 1984 Supergirl film from Tri-Str Pictures. From 2015–2021, Slater portrayed Eliza Danvers, the adopted mother of Kara Danvers on the Supergirl television series.

In 2020, Tom Welling and Erica Durance reprised their roles as Clark Kent and Lois Lane in The CW "Crisis on Infinite Earths" crossover event.